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Which of the following statements describes NAD+?


A) NAD+ is reduced to NADH during glycolysis, pyruvate oxidation, and the citric acid cycle.
B) NAD+ has more chemical energy than NADH.
C) NAD+ is oxidized by the action of hydrogenases.
D) NAD+ can donate electrons for use in oxidative phosphorylation.
E) In the absence of NAD+, glycolysis can still function.

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The ATP made during glycolysis is generated by


A) substrate-level phosphorylation.
B) electron transport.
C) photophosphorylation.
D) chemiosmosis.
E) oxidation of NADH to NAD+.

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The direct energy source that drives ATP synthesis during respiratory oxidative phosphorylation in eukaryotic cells is


A) oxidation of glucose to CO2 and water.
B) the thermodynamically favorable flow of electrons from NADH to the mitochondrial electron transport carriers.
C) the final transfer of electrons to oxygen.
D) the proton-motive force across the inner mitochondrial membrane.
E) the thermodynamically favorable transfer of phosphate from glycolysis and the citric acid cycle intermediate molecules of ADP.

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When an individual is exercising heavily and when the muscle becomes oxygen-deprived, muscle cells convert pyruvate to lactate. What happens to the lactate in skeletal muscle cells?


A) It is converted to NAD+.
B) It produces CO2 and water.
C) It is taken to the liver and converted back to pyruvate.
D) It reduces FADH2 to FAD+.
E) It is converted to alcohol.

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Why are carbohydrates and fats considered high-energy foods?


A) They have a lot of oxygen atoms.
B) They have no nitrogen in their makeup.
C) They can have very long carbon skeletons.
D) They have a lot of electrons associated with hydrogen.
E) They are easily reduced.

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Most CO2 from catabolism is released during


A) glycolysis.
B) the citric acid cycle.
C) lactate fermentation.
D) electron transport.
E) oxidative phosphorylation.

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Which metabolic pathway is common to both fermentation and cellular respiration of a glucose molecule?


A) the citric acid cycle
B) the electron transport chain
C) glycolysis
D) synthesis of acetyl CoA from pyruvate
E) reduction of pyruvate to lactate

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Starting with citrate, which of the following combinations of products would result from three acetyl CoA molecules entering the citric acid cycle (see Figure 7.1) ?


A) 1 ATP, 2 CO2, 3 NADH, and 1 FADH2
B) 2 ATP, 2 CO2, 3 NADH, and 3 FADH2
C) 3 ATP, 3 CO2, 3 NADH, and 3 FADH2
D) 3 ATP, 6 CO2, 9 NADH, and 3 FADH2
E) 38 ATP, 6 CO2, 3 NADH, and 12 FADH2

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Which statement best supports the hypothesis that glycolysis is an ancient metabolic pathway that originated before the last universal common ancestor of life on Earth?


A) Glycolysis is widespread and is found in the domains Bacteria, Archaea, and Eukarya.
B) Glycolysis neither uses nor needs O2.
C) Glycolysis is found in all eukaryotic cells.
D) The enzymes of glycolysis are found in the cytosol rather than in a membrane-enclosed organelle.
E) Ancient prokaryotic cells, the most primitive of cells, made extensive use of glycolysis long before oxygen was present in Earth's atmosphere.

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Where do the catabolic products of fatty acid breakdown enter into the citric acid cycle?


A) pyruvate
B) malate or fumarate
C) acetyl CoA
D) α-ketoglutarate
E) succinyl CoA

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