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In resistant patients, ______ combined with antidepressant medication leads to significant improvement in depression scores.


A) aversive therapy
B) cognitive behavioral therapy
C) systematic desensitization
D) ketamine

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When were the earliest reported case of a disorder with psychotic-like symptoms?


A) 20 years ago
B) 100 years ago
C) 4,000 years ago
D) 100,000 years ago

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The ______ Prozac (also called fluoxetine) ______.


A) atypical antidepressant; inhibits serotonin reuptake
B) monoamine oxidase inhibitor; inhibits dopamine reuptake
C) SNRI; stimulates serotonin production
D) second-generation antidepressant; stimulates dopamine production

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______ of those who attempt suicide have a diagnosable psychiatric illness.


A) 90%
B) 80%
C) 70%
D) 60%

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The high concordance rate for affective disorders in identical twins drops only slightly when they are reared apart, suggesting that ______.


A) there is little to no environmental influence
B) the most important environmental influences occur during the prenatal period
C) when one twin is diagnosed, the other twin will be diagnosed at some point in their life
D) environmental influence is not important

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Which of the following is FALSE regarding schizophrenic patients who do not respond to the typical dopamine blocking drugs?


A) Some showed just as much dopamine blockage as responsive patients.
B) Some showed over 90% dopamine blockage compared to responsive patients.
C) Some showed significantly lower levels of dopamine blockage compared to responsive patients.
D) Some showed a deficit in dopamine levels.

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Which of the following statements about the aberrant salience hypothesis is FALSE?


A) Increased dopamine levels increase attentional processes in schizophrenia.
B) Increased dopamine levels increase motivational processes in schizophrenia.
C) Increased dopamine levels trigger negative symptoms of schizophrenia.
D) Increased dopamine levels cause ordinary stimuli in the environment to be perceived as salient.

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Which neurotransmitter circuit is implicated in the extrapyramidal effects of FGA drugs used to treat schizophrenia?


A) dopamine
B) glutamate
C) acetylcholine
D) serotonin

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Which of the following imaging techniques is BEST suited for observing the quality of neural connections in the schizophrenic brain?


A) diffusion tensor imaging
B) functional magnetic resonance imaging
C) positron emission tomography
D) electroencephalogram

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Individuals who carry the VAL66MET allele ______.


A) show resistance to fear extinction procedures
B) are more predisposed to develop PTSD
C) are mostly men
D) show a hyperactive connection between the prefrontal cortex and amygdala

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OCD can be caused by an autoimmune attack on the basal ganglia.

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What is a relatively new treatment used in OCD patients who do not respond to drug therapy?


A) ECT
B) TMS
C) DBS
D) EEG

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Which part of the prefrontal cortex, when damaged, shows effects similar to the negative symptoms of schizophrenia?


A) the ventrolateral prefrontal cortex
B) the superior part of the prefrontal cortex
C) the dorsolateral prefrontal cortex
D) the inferior part of the prefrontal cortex

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All of the following most likely account for the discordance rate of schizophrenia among twins EXCEPT ______.


A) epigenetic modifications
B) prenatal malnutrition
C) prenatal exposure to influenza
D) identical genomes

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How many chromosomal sites associated with suicide risk have been discovered?


A) 5
B) 6
C) 7
D) 8

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Which of the following is NOT an example of external environmental challenges for the onset of schizophrenia?


A) poor nutrition
B) job difficulties
C) bereavement
D) divorce

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Which of the following is NOT true about the genes implicated in affective disorders?


A) The short allele for the serotonin transporter shows exaggerated responses to fearful facial expressions.
B) The VAL66MET gene for BDNF increases the risk of depression.
C) Dysregulation of the immune system is correlated with depressive disorders.
D) Many of the genes are different in men and women.

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Which of the following is a reported reason as to why adolescence is a particularly significant period in the development of schizophrenia?


A) Hormonal changes occur.
B) Substance use typically begins in this period.
C) Sexual activity begins during this time, which can increase stress levels.
D) Frontal myelination is occurring during this period.

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In a recent study, mice that were injected with a drug that mimics ______, a compound that normally builds up during wakefulness, showed antidepressant benefits without sleepiness:


A) serotonin
B) caffeine
C) adenosine
D) glutamate

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The genes responsible for affective disorders are frequently sex specific. What does this help explain?


A) Fewer genes are found in women than men linked to affective disorders, explaining the higher rate of women affected by affective disorder.
B) Women tend to have higher rates of suicide than men.
C) Risk factors are correlated to different locations on chromosomes for men and women.
D) none of these

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